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(A) Photographic images of mouse livers taken at different time points after NICD/AKT plasmid injection. Small tumors (arrows) were visible as early as 3.5 weeks after injection. (B) H&E stainings of corresponding liver sections show rapidly expanding tumors replacing the normal liver parenchyma. Original magnification, ×40. At least 15 liver sections from 3 mice were analyzed for each time point.
