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. 2012 Jul 17;122(8):2989–3001. doi: 10.1172/JCI64427

Figure 4. Genetic panel study reveals no significant phenotypic changes in B6 mice with single A/J chromosome substitutions.

Figure 4

A CSS panel was used in which single chromosomes (Chr) 1–19, X, Y, and mitochondrial DNA (Mito) from A/J mice were substituted into the B6 background. (A) An example of the genetic makeup of chromosome 8–substituted mice, which possess only chromosome 8 from A/J mice and all other chromosomes from B6 mice. No significant functional or structural changes were observed at 8 months when (B) 11-cis-retinal levels and (C) nuclei numbers in the ONL were compared in all CSSs relative to B6 mice. Representative (D) HPLC chromatograms and (E) plastic block sections of A/J, B6, and Chr 8 mice. Scale bars: 40 μm (E).