Figure 1.

Effects of Flu on I _K(DR) in NSC-34 neuronal cells. Cells were bathed in Ca²⁺-free Tyrode's solution containing tetrodotoxin (1 μM) and CdCl₂ (0.5 mM). (a) Superimposed current traces in the absence (upper) and presence (lower) of 3 μM Flu. The cell examined was held at −50 mV and various potentials ranging from −100 to +40 mV in 10-mV increments, as shown in the uppermost part of (a), were applied. (b) Averaged  I-V  relations for K⁺ currents measured at the end of each voltage pulse in the absence (■) and presence (□) of 3 μM Flu (mean ± SEM; n = 9–13 for each point). (c) The  I-V  relationship of Flu-sensitive current (i.e., the difference of averaged K⁺ currents between the absence and presence of 3 μM Flu).