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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Behav Brain Res. 2012 Jun 17;234(1):51–60. doi: 10.1016/j.bbr.2012.06.006

Figure 2.

Figure 2

Graphs represent non-cumulative food consumption in ethanol drinking (EE) and ethanol naïve (EN) rats in two 2-h intervals post-infusion of the selective MC4-R antagonist HS014 (0.02 or 0.05 μg), or isotonic saline into the LH (a), NAc (b) or VTA (c). Pair-wise comparisons showed that relative to saline, administration of HS014 into the LH increased feeding in ethanol naïve (EN) and ethanol drinking (EE) rats at both doses and two 2-h intervals. NAc-infused HS014 triggered an orexigenic effect at both doses and during the two 2-h intervals tested only in ethanol naïve rats. VTA infusion of the low dose of HS014 significantly increased feeding during the first 2-h interval relative to saline and only in EN rats; it did not significantly affect food intake in any group over the second interval tested. All values are means ± S.E.M.