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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Neuropharmacology. 2012 Jun 6;63(5):769–775. doi: 10.1016/j.neuropharm.2012.05.040

Fig. 1. Acute treatment with the NMDA receptor antagonist, memantine, has no effect on the impaired motor coordination of one-month-old Cln3Δex1-6 mice.

Fig. 1

An accelerating rotarod (from 0 to 24 rpm in 240 s) was used to measure the motor coordination of one-month-old wild type (WT) and Cln3Δex1-6 mice. Two hours and thirty minutes after the end of the Pre-treatment rotarod test, mice were intraperitoneally injected with either the uncompetitive NMDA receptor antagonist, memantine (1 and 5 mg/kg), or the vehicle of the drug (sterile 0.9% NaCl). The Post-treatment rotarod test began thirty minutes after the treatment. Columns and bars represent mean ± S.E.M. of the time (s) mice were able to stay on the rotating rod (n=9–14). Repeated measures two-way ANOVA with Bonferroni’s test for pairwise multiple comparison was applied to compare the different treatment groups (*p<0.05, ***p <0.001 and ****p <0.0001 as compared to vehicle-injected WT mice).