Table 6.
Demographic, anthropometric, serum and urinary characteristics of calcium stone-forming subjects from Dallas and number of features of the MSa
| Number of MS features |
P for trend | |||||
|---|---|---|---|---|---|---|
| 0 (N = 21) | 1 (N = 32) | 2 (N = 29) | 3 (N = 22) | ≥4 (N = 24) | ||
| Gender, male/female; n ( % ) | 7/14 (36/67) | 14/18 (44/56) | 23/6 (79/21) | 13/9 (59/41) | 15/9 (63/37) | 0.01 |
| Ethnicity, White/Asian/Hispanic/American Indian | 20/0/1/0 | 30/1/1/0 | 25/2/0/2 | 19/1/2/0 | 24/0/0/0 | 0.4 |
| Age, years | 41 ± 11 | 39 ± 11 | 46 ± 13 | 47 ± 12 | 43 ± 10 | 0.1 |
| BMI, kg/m2 | 22.3 ± 2.8 | 25.0 ± 3.2 | 29.4 ± 5.9 | 30.5 ± 6.3 | 40.0 ± 9.9 | < 0.0001 |
| Systolic BP, mmHg | 114 ± 9 | 121 ± 17 | 125 ± 12. | 128 ± 13 | 128 ± 13 | 0.001 |
| Diastolic BP, mmHg | 70 ± 5 | 74 ± 10 | 79 ± 10 | 81 ± 8 | 83 ± 11 | < 0.0001 |
| Serum | ||||||
| Glucose, mmol/L | 4.9 ± 0.3 | 4.9 ± 0.4 | 5.1 ± 0.5 | 5.2 ± 0.4 | 6.4 ± 1.9 | < 0.0001 |
| Triglycerides, mmol/L | 0.81 ± 0.27 | 1.00 ± 0.42 | 1.54 ± 0.69 | 2.46 ± 1.29 | 2.91 ± 1.82 | < 0.0001 |
| HDL cholesterol, mmol/L | 1.76 ± 0.52 | 1.33 ± 0.37 | 1.07 ± 0.18 | 1.07 ± 0.21 | 1.06 ± 0.19 | < 0.0001 |
| Urine | ||||||
| Total volume, L/day | 1.7. ± 0.97 | 1.84 ± 1.16 | 2.00 ± 0.86 | 1.66 ± 0.70 | 2.68 ± 1.58 | 0.02 |
| Calcium, mmol/day | 5.2 ± 2.3 | 5.4 ± 2.4 | 6.6 ± 3.5 | 5.2 ± 2.5 | 7.0 ± 4.0 | 0.09 |
| Oxalate, mmol/day | 356 ± 141 | 336 ± 126 | 373 ± 159 | 399 ± 198 | 504 ± 203 | 0.001 |
| Uric acid, mmol/day | 2.96 ± 0.90 | 3.23 ± 1.14 | 3.57 ± 1.20 | 3.20 ± 1.31 | 4.34 ± 1.50 | 0.001 |
| pH | 6.23 ± 0.40 | 6.15 ± 0.44 | 6.05 ± 0.41 | 5.95 ± 0.37 | 5.88 ± 0.50 | 0.002 |
| Citrate, mEq/day | 7.0 ± 3.3 | 8.3 ± 4.8 | 7.0 ± 5.0 | 6.1 ± 3.3 | 9.6 ± 6.9 | 0.3 |
| Sulfate, mmol/day | 17.2 ± 7.4 | 17.2 ± 7.9 | 19.1 ± 7.6 | 16.3 ± 9.3 | 23.5 ± 9.8 | 0.03 |
| NAE, mEq/day (calculated) | 37.4 ± 18.8 | 41.3 ± 22.7 | 50.8 ± 22.0 | 52.7 ± 26.5 | 63.1 ± 36.3 | 0.0004 |
| NH4+/NAE | 0.87 (0.73–0.98) | 0.83 (0.69–0.96) | 0.72 (0.65–0.82) | 0.74 (0.61–0.81) | 0.65 (0.60–0.93) | 0.001 |
| Creatinine clearance, mL/s | 1.68 ± 0.45 | 1.80 ± 0.48 | 1.77 ± 0.45 | 1.67 ± 0.57 | 2.38 ± 0.72 | 0.0004 |
| Supersaturation indices | ||||||
| SI CaOx (volume adjusted) | 4.46 ± 1.80 | 4.01 ± 1.81 | 4.93 ± 2.12 | 4.71 ± 1.74 | 6.16 ± 3.71 | 0.009 |
| SI Br (volume adjusted) | 1.39 ± 0.81 | 1.47 ± 0.80 | 1.71 ± 0.98 | 1.36 ± 0.78 | 1.54 ± 1.02 | 0.7 |
aValues are expressed as mean ± SD except where otherwise noted.