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Figure 3. (A) mTORC1-SREBP-mediated lipogenesis. Activated mTORC1 phosphorylates lipin1, which resides in the cytoplasm and allows nuclear SREBP binding to lipogenic target genes resulting in increased lipogenesis. (B) Inactivation of mTORC1 results in nuclear entry of lipin 1, which disrupts SREBP binding to target genes, thus suppressing lipogenesis (modified according to Peterson et al.72
