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Figure 1. PCAF appears to be present constitutively at the p21 promoter. Top of the panel, in the absence of a stimulus, PCAF cannot acetylate histones in the promoter bound nucleosomes (blue). Upon activating signals, p53 binds to the p21 promoter, triggering PCAF-dependent histone H3 acetylation and expression of the p21 gene, see bottom part of Figure.
