Table 1. Top canonical pathways. cDNA microarrays and gene pathway analysis reveal miR-494 regulated canonical pathways. Ingenuity pathway analysis summary reports that the top two canonical pathways modulated by miR-494 are “Mitotic roles of Polo-like kinase” and “Cell cycle G2/M checkpoint regulation.”.
| Name | p-value | Ratio |
|---|---|---|
|
Mitotic Roles of Polo-Like Kinase |
8.28E-06 |
6/58(0.103) |
|
Cell Cycle: G2/M DNA Damage Checkpoint Regulation |
2.00E-05 |
5/44(0.114) |
|
Cell Cycle: G1/S Checkpoint Regulation |
9.89E-05 |
5/58/(0.086) |
|
Citrate Cycle |
1.06E-04 |
4/57(0.07) |
| Small Cell Lung Cancer Signaling | 3.62E-04 | 5/88(0.057) |