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URB597 treatment attenuates the age-related increase in inflammatory cytokines in hippocampus. IL-1β, TNFα, and IL-6 mRNA were increased in hippocampal tissue prepared from aged, compared with young, rats; a significant age x treatment effect was observed for IL-1β and TNFα (F(1,22) = 5.096, **P < 0.01; and F(1,21) = 16.16, **P < 0.01; 2-way ANOVA; a and b, respectively) and a significant age effect was observed in the case of IL-6 (F(1,21) = 29.98, ++P < 0.001; c).
