Table 3.

Multivariable analysis of the effect of intervention group and empiric antibiotics on hospital mortality

	OR (95% CI)	P value
Intervention effect base model:
Prompted group	0.41 (0.18-0.92)	0.032
APACHE IV predicted mortality	47.8 (10.3-222)	<0.001
Empiric antibiotics mediating effect model:a
Prompted group	0.50 (0.21-1.2)	0.11
APACHE IV predicted mortality	37.0 (7.6-180)	<0.001
Empiric antibiotics 4–6days	2.1 (0.76-6.0)	0.15
Empiric antibiotics ≥7days	2.5 (0.92-6.6)	0.074
Independent empiric antibiotics model:a
APACHE IV predicted mortality	30.5 (6.6-140)	<0.001
Empiric antibiotics 4–6days	2.3 (0.81-6.3)	0.12
Empiric antibiotics ≥7days	3.1 (1.2-8.0)	0.019

^a Category 1 (empiric antibioticduration 1–3days) used as reference

OR: Odds ratio ofdeath. CI: confidence interval.