Table 1.
M1 receptor and phosphatase effects on KV channel
| α subunit | Auxiliary subunit | M1R | Dr-VSP | Pseudojanin or FKBP-Inp54p (in case of KV7.1) |
| KV1.1 | KVβ1.1 | Slowing of inactivationa | No effect | No effect |
| KV1.3 | None | No effect | ND | No effect |
| KV1.4 | None | No effect | No effect | No effect |
| KV1.5 | ± KVβ1.3 | No effect | No effect | No effect |
| KV2.1 | None | ∼22% decrease | No effect | No effect |
| KV3.4 | None | Slowing of inactivationa | No effect | No effect |
| KV4.2/KV4.3 | None | No effect | No effect | ND |
| KV4.2/KV4.3 | KChIP1 | ND | No effect | ND |
| KV4.2/KV4.3 | KChIP1 + DPP6-s | ND | No effect | ND |
| KV4.2/KV4.3 | KChIP2 | ND | No effect | ND |
| KV7.1 (KCNQ1) | KCNE1 | ND | Strong inhibition | Strong inhibition |
| KV7.2/7.3 (KCNQ2/Q3) | None | Strong inhibitiona | Strong inhibitiona | Strong inhibition |
| KV11.1 (hERG) | None | ND | No effect | ND |
| KV11.1 (hERG) | KCNE2 | ∼30% decrease | No effect | No effect |
| Kir2.1 | None | No effect | ∼45% decrease | Strong inhibition |
a
These effects duplicate published work, see Discussion.