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. 2012 Aug;140(2):139–158. doi: 10.1085/jgp.201110706

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© 2012 Mukherjee et al.

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Figure 2. — Kinetic parameters of hRyR2 gating. Data were obtained from the full range (0–500 µM) of Ca²⁺ activation for 12 individual channels. (A) Effect of [Ca²⁺]_cyt on P_o where a sigmoidal relationship is observed upon fitting the pooled data points with a log [agonist] versus response curve (EC₅₀ = 1.65 ± 0.43 µM; Hill coefficient = 1.78 ± 0.69; n = 12 datasets). (B) Pooled data points from the 12 channels showing the relationship between P_o and T_c. (C) The relationship of P_o with T_o. The data points are color coded according to their origin from the 12 individual channels as shown in Fig. S1.