Table 3. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of different tests for the diagnosis of S.mansoni.

	Setting A				Setting B				Setting C				All settings A-B-C
	Sensitivity	Specificity	PPV	NPV	Sensitivity	Specificity	PPV	NPV	Sensitivity	Specificity	PPV	NPV	Sensitivity	Specificity	PPV	NPV
	% CI	% CI	% CI	% CI	% CI	%CI	% CI	% CI	% CI	% CI	% CI	% CI	% CI	% CI	% CI	% CI
Nine Kato-Katz as ‘reference’ diagnostic test
Single Kato-Katz (stool day 1)	58	100	100	80.7	56.8	100	100	47.6	49.0	100	100	52.4	53.8	100	100	58.1
	(44.3–71.7)	/	/	(73.3–88.1)	(49.5–64.1)	/	/	(39.5–55.7)	(41.2–56.9)	/	/	44.8–60.0)	(48.8–58.8)	/	/	(53.4–62.8)
Triplicate Kato-Katz (stool day 1)	66	100	100	83.8	68.2	100	100	55.2	69.7	100	100	64.9	68.5	100	100	67
	(52.9–79.1)	/	/	(76.8–90.9)	(61.3–75.1)	/	/	(46.5–63.9)	(62.4–76.9)	/	/	(56.8–73.0)	(63.8–73.2)	/	/	(62.2–71.9)
Triplicate CCA	92	54.5	53.5	92.3	90.9	34.8	78.0	60	96.1	69.0	71.3	81.8	93.2	40.6	71	79.2
	(84.4–99.5)	(44.1–64.9)	(42.9–64.0)	(85.1–99.6)	(86.7–95.2)	(23.5–46.0)	(72.4–83.7)	(44.8–75.2)	(93.1–99.2)	(59.2–78.7)	(65.2–77.4)	(68.7–95.0)	(90.6–95.7)	(34.4–46.7)	(67.0–75.0)	(72.1–86.3)
Single CCA (urine day 1)	82	64.7	56.9	86.4	82.4	62.3	84.8	58.1	87.7	42.5	78.6	72.5	84.5	61.5	77.4	71.8
	(71.6–92.6)	(54.8–74.8)	(45.5–68.4)	(78.1–94.6)	(76.8–88.0)	(50.9–73.8)	(79.4–90.2)	(46.9–69.3)	(82.6–92.9)	(32.1–52.9)	(72.5–84.7)	(61.9–83.0)	(80.9–88.1)	(55.4–67.6)	(73.4–81.4)	(65.7–77.9)
CCA-L	46	100	100	76.5	68.8	91.3	95.3	53.4	55.5	92.0	92.5	53.7	60.4	94.7	94.7	60.5
	(32.2–59.8)	/	/	(63.8–84.3)	(61.9–75.6)	(84.7–98.0)	(91.6–99.0)	(44.4–62.4)	(47.7–63.3)	(86.2–97.7)	(87.1–97.8)	(45.7–61.7)	(55.5–65.3)	(91.9–97.5)	(91.8–97.5)	(55.6–65.4)
Combined results as ‘reference’ diagnostic test
Single Kato-Katz (stool day 1)	32.2	100	100	44.0	45.2	100	100	16.6	35.3	100	100	16.3	39.	100	100	23.6
	(22.6–41.9)	/	/	(34.7–53.4)	(38.7–51.8)	/	/	(10.5–22.6)	(29.0–41.7)	/	/	(10.7–21.9)	(34.8–43.1)	/	/	(19.5–27.6)
Triplicate Kato-Katz (stool day 1)	36.7	100	100	45.7	45.3	100	100	19.2	50.2	100	100	20.1	49.7	100	100	27.2
	(26.7–46.6)	/	/	(36.2–55.2)	(47.7–60.9)	/	/	(12.3–26.1)	(43.5–56.9)	/	/	(13.4–26.9)	(45.3–53.9)	/	/	(22.6–31.8)
Single CCA (urine day 1)	80	100	100	92.3	77.4	100	100	60	80.5	100	100	81.8	79.1	100	100	79.2
	(71.7–88.3)	/	/	(85.1–99.6)	(71.9–82.9)	/	/	(44.8–75.2)	(75.2–85.8)	/	/	(68.7–95.0)	(75.6–82.6)	/	/	(72.1–86.3)
Triplicate CCA	95.6	100	100	72.7	92.8	100	100	32.4	97.2	100	100	39.1	95.1	100	100	47.4
	(91.3–99.8)	/	/	(62.0–83.5)	(89.3–96.2)	/	/	(21.8–43.1)	(95.0–99.4)	/	/	(27.6–50.6)	(93.2–96.9)	/	/	(40.6–54.1)
CCA-L	25.6	100	100	41.7	57.5	100	100	20.3	43.3	100	100	18.1	46.2	100	100	25.9
	(16.5–34.6)	/	/	(32.7–50.8)	(50.9–64.0)	/	/	(13.1–27.6)	(36.6–49.9)	/	/	(11.9–24.3)	(41.9–50.5)	/	/	(21.5–30.3)