Table 2. HBV and HIV response to 3TC in HIV-1/HBV co-infected patients during 12 months of treatment.

	Overall (N = 30)		HBeAg positive (N = 19)		HBeAg negative (N = 11)		p-valuea
	n	%[95%CI] or median [IQR]	n	%[95%CI] or median [IQR]	n	%[95%CI] or median [IQR]
HBV DNA suppressionb
at 3 months	14	47 [28–66]	6	32 [13–57]	8	73 [39–94]	0.06
at 12 months	20	67 [47–83]	9	47 [24–71]	11	100 [72–100]	0.004
HIV load ≤50 cp/mL
at 3 months	22	73 [54–88]	13	68 [43–87]	9	82 [48–98]	0.67
at 12 months	22	73 [54–88]	14	74 [49–91]	8	73 [39–94]	1.00
HIV RNA reduction
at 3 months (log10 cp/mL)		2.92 [2.54–3.53]		2.93 [2.14–3.48]		2.91 [2.54–4.08]	0.53
at 12 months (log10 cp/mL)		2.92 [1.52–3.45]		2.93 [1.52–3.32]		2.91 [1.17–4.08]	0.78

^aFisher’s exact test or Wilcoxon rank-sum test were used.

^bHBV DNA suppression was defined as serum HBV DNA level equal or below 150 or 2.18 log₁₀ IU/mL.