Table 3. Associations between the cytoplasmic expression of RhoT1, Smad4, p16 and the presence of lymph node metastasis and perineural invasion.

Variables	lymph node metastasis			perineural invasion
	Positive	Negative	P value	Positive	Negative	P value
	n = 65	n = 97		n = 83	n = 79
RhoT1 expression
high	12	43	0.003	23	32	0.198
low	53	54		60	47
Smad4 expression
high	8	35	0.032	25	18	0.304
low	57	62		58	61
p16 expression
high	7	29	0.042	20	16	0.35
Low	58	68		63	63