Table 4. Associations between the cytoplasmic expression of RhoT1, Smad4, p16 and the clinicopathological features.

Variables	RhoT1 expression			Smad4 expression			p16 expression
	low	high	P value	low	high	P value	low	high	P value
Age (years)
<60	60	29	0.922	70	19	0.097	70	19	0.299
≧60	47	26		49	24		56	36
Gender
female	36	24	0.660	38	22	0.382	48	12	0.897
male	71	31		81	21		78	24
Location
head	80	37	0.876	88	29	0.744	94	23	0.468
body/rear	27	18		31	14		32	13
Size
<4	47	27	0.324	52	22	0.186	59	15	0.114
≧4	60	28		67	21		57	21
Differentiation
moderate/well	81	45	0.278	94	37	0.808	102	29	0.149
poor	21	10		25	6		24	7
AJCC stage
stage I	46	34	0.191	50	30	0.242	56	24	0.33
stage II	60	20		68	12		69	11
stage IV	1	1		1	1		1	1