Table 5. Univariate and multivariable Cox regression analysis of overall survival (n = 70).

Features	Univariate analysis		Multivariable analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Tumor features
age (years),<60 v ≧ 60	1.38(0.77 to 2.46)	0.273
sex, female v male	0.60(0.32 to 1.13)	0.114
tumor location, head v body/rear	1.08(0.59 to 1.99)	0.787
tumor size, <4 v ≧ 4	1.41(0.79 to 2.52)	0.239
tumor differentiation, poor v moderate/well	2.48(1.32 to 4.64)	0.004	2.49(1.24 to 5.01)	0.010
AJCC stage, II v I	1.82(1.01 to 3.28)	0.044	1.29(0.46 to 3.66)	0.623
LNM, positive v negative	2.09(1.16 to 3.77)	0.014	2.35(0.84 to 6.57)	0.101
PNI, positive v negative	1.57(0.88 to 2.82)	0.124
Expression of proteins, low v high
RhoT1	1.92(1.02 to 3.61)	0.042	1.43(0.72 to 2.84)	0.300
Smad4	1.94(0.98 to 3.84)	0.056
p16	1.62(0.82 to 3.20)	0.162

Note: HR: Hazard ratio; LNM: lymph node metastasis; PNI: perineural Invasion.