Table 2. Cox univariate and multivariate analysis of OS in HM and UAMS-TT2 patients’ cohorts.
| Univariate Cox analysis - Overall survival | ||||
| A | HM | LR-TT2 | ||
| HR | P | HR | P | |
| SCScore | 9 | 2.60E-11 | 6 | 3.50E-10 |
| UAMS-HRS | 2.4 | 1.40E-02 | 4.7 | 4.80E-13 |
| IFM score | 2.5 | 1.90E-02 | 1.8 | 4.00E-03 |
| GPI | 2.6 | 1.60E-04 | 1.8 | 2.20E-04 |
| Spike MMSET | 3.3 | 4.70E-04 | 2.2 | 3.20E-04 |
| del17p | 3.4 | 2.00E-02 | 2.5 | 3.70E-04 |
| ISS | 2 | 9.70E-04 | 1.6 | 0.000055 |
| β2M | 1.1 | 4.20E-05 | 1.1 | 0.000000049 |
| Alb | 0.47 | 1.40E-02 | 0.94 | 0.00012 |
| Multivariate Cox analysis - Overall survival | ||||
| B | HM | LR-TT2 | ||
| HR | P | HR | P | |
| SCScore | 8.9 | 3.50E-09 | 4 | 2.60E-08 |
| UAMS-HRS | 1 | NS | 2.4 | 4.70E-04 |
| SCScore | 8.3 | 3.10E-10 | 5.7 | 3.40E-15 |
| IFM score | 1.7 | NS | 1.2 | NS |
| SCScore | 8.5 | 2.50E-10 | 5.4 | 7.90E-15 |
| GPI | 2.2 | 6.30E-04 | 1.4 | 3.60E-02 |
| SCScore | 13 | 4.20E-08 | 7.2 | 1.00E-13 |
| Spike MMSET | 0.62 | NS | 0.74 | NS |
| SCScore | 9.1 | 1.20E-10 | 5.9 | 0.00E+00 |
| del17p | 3.2 | 3.20E-02 | 2.3 | 1.30E-03 |
| SCScore | 7.6 | 1.80E-09 | 5.4 | 2.10E-15 |
| ISS | 1.6 | 1.60E-02 | 1.4 | 0.0033 |
| SCScore | 8 | 2.10E-09 | 5.1 | 2.20E-14 |
| β2M | 1 | NS | 1.1 | 0.0002 |
| SCScore | 8 | 8.70E-10 | 5.3 | 8.70E-15 |
| Alb | 0.65 | NS | 0.96 | 0.021 |
| Multivariate Cox analysis - Overall survival | ||||
| C | HM | LR-TT2 | ||
| HR | P | HR | P | |
| SCScore | 6.4 | 0.0012 | 3.4 | 0.00013 |
| del17p | 1.9 | NS | 2.4 | 0.00093 |
| ISS | 1.4 | NS | 1.3 | 0.013 |
| UAMS-HRS | 0.68 | NS | 2.3 | 0.0078 |
| IFM score | 0.63 | NS | 0.9 | NS |
| Spike MMSET | 1.7 | NS | 1.1 | NS |
| GPI | 2.3 | 0.01 | 1.1 | NS |
A) Cox univariate analysis of overall survival. The prognostic factors were tested as single variable. B) Cox multivariate analysis of overall survival. The SCScore were tested together with each of the prognostic factors. C) Cox multivariate analysis of overall survival using all prognostic factors together. Hazard ratios (HR) and P-values are shown. NS, Not Significant at a 5% threshold; GPI, gene expression based proliferation index; ISS, International Staging System; UAMS-HRS, high-risk score from UAMS; IFM, Intergroupe Francophone du Myelome.