Table 3. Drug resistance rates of K. pneumoniae isolates.
| Antimicrobial category | Drugsa | Range (µg/mL) | MIC50 (µg/mL) | MIC90 (µg/mL) | ESBL positive n = 101 (%) | ESBL negative n = 122 (%) | Total n = 223 (%) |
| Penicillins (99.6%, 222/223) | AMP | ≤2–≧32 | ≥32 | ≥32 | 101 (100) | 121 (99.2) | 222 (99.6) |
| Antipseudomonal penicillins + beta-lactamase inhibitors (22.4%, 50/223) | TZP | ≤4–≧128 | ≤4 | ≥128 | 29 (28.7) | 21 (17.2) | 50 (22.4) |
| Penicillins + beta-lactamase inhibitors (51.6%, 115/223) | SAM | ≤2–≧32 | 16 | ≥32 | 88 (87.1) | 27 (22.1) | 115 (51.6) |
| 1st and 2nd generation cephalosporins (51.1%, 114/223) | CFZ | ≤4–≧64 | 32 | ≥64 | 96 (95.0) | 18 (14.8) | 114 (51.1) |
| 3rd and 4th generation cephalosporins (49.3%, 110/223) | CRO | ≤1–≧64 | ≤1 | ≥64 | 95 (94.1) | 15 (12.3) | 110 (49.3) |
| CAZ | ≤1–≧64 | ≤1 | ≥64 | 95 (94.1) | 15 (12.3) | 110 (49.3) | |
| FEP | ≤1–≧64 | ≤1 | ≥64 | 96 (95.0) | 12 (9.8) | 108 (48.4) | |
| Cephamycins (68.6%, 153/223) | CTT | ≤4–≧64 | ≤4 | ≤4 | 43 (42.6) | 110 (90.2) | 153 (68.6) |
| Carbapenems (7.2%, 16/223) | ETP | ≤0.5–≧8 | ≤0.5 | ≤0.5 | 5 (5.0) | 11 (9.0) | 16 (7.2) |
| IMP | ≤1–≧16 | ≤1 | ≤1 | 3 (3.0) | 10 (8.2) | 13 (5.8) | |
| Monobactams (48.9%, 109/223) | ATM | ≤1–≧64 | ≤1 | ≥64 | 96 (95.0) | 13 (10.7) | 109 (48.9) |
| Fluoroquinolones (40.4%, 90/223) | CIP | ≤0.25–≧4 | 1 | ≥4 | 63 (62.4) | 27 (22.1) | 90 (40.4) |
| LVX | ≤0.25–≧8 | 1 | ≥8 | 63 (62.4) | 27 (22.1) | 90 (40.4) | |
| Aminoglycosides (49.3%, 110/223) | GM | ≤1–≧16 | ≤1 | ≥16 | 70 (69.3) | 22 (18.0) | 92 (41.3) |
| TOB | ≤1–≧16 | ≤1 | ≥16 | 82 (81.2) | 27 (22.1) | 109 (48.9) | |
| AMK | ≤2–≧64 | ≤2 | 16 | 39 (38.6) | 15 (12.3) | 54 (24.2) | |
| Folate pathway inhibitors (52.9%, 118/223) | SXT | ≤20–≧320 | ≥320 | ≥320 | 90 (89.1) | 28 (23.0) | 118 (52.9) |
| Nitrofurantoin (85.2%, 190/223) | FD | ≤16–≧512 | 64 | ≥512 | 89 (88.1) | 101 (82.8) | 190 (85.2) |
a
Abbreviation of drugs: AMP, Ampicillin; TZP, Piperacillin/Tazobactam; SAM, Ampicillin/Sulbactam; CFZ, Cefazolin; CRO, Ceftriaxone; CAZ, Ceftazidime; FEP, Cefepime; CTT, Cefotetan; ETP, Ertapenem; IMP, Imipenem; ATM, Aztreonam; CIP, Ciprofloxacin; LVX, Levofloxacin; GM, Gentamycin; TOB, Tobramycin; AMK, Amikacin; SXT, Trimethoprim-Sulfamethoxazole; FD, Furadantin.