Table 4. Percentage of beta-lactamase antibiotics resistance-associated genes detected in K. pneumoniae isolates.
Target antimicrobial category | Resistance-associated genes | Resistance-associated genes detected in phenotypic resistant isolates, n/Na (%) | Resistance-associated genes detected in phenotypic susceptible isolates, n/Nb (%) | Resistance-associated genes detected in all isolates, n/Nc (%) |
Antipseudomonal penicillins + beta-lactamase inhibitors, penicillins + beta-lactamase inhibitors, 1st and 2nd generation cephalosporins, 3rd and 4th generation cephalosporins, cephamycins (n = 204) | bla CTX-M-1 | 35/204 (17.2) | 2/19 (10.5) | 37/223 (16.6) |
bla CTX-M-2 | 1/204 (0.5) | 1/19 (5.3) | 2/223 (0.9) | |
bla CTX-M-3 | 31/204 (15.2) | 1/19 (5.3) | 32/223 (14.3) | |
bla CTX-M-8 | 20/204 (9.8) | 2/19 (10.5) | 22/223 (9.9) | |
bla CTX-M-9 | 18/204 (8.8) | 2/19 (10.5) | 20/223 (9.0) | |
bla CTX-M-14 | 37/204 (18.1) | 0 | 37/223 (16.6) | |
bla CTX-M-15 | 34/204 (16.7) | 0 | 34/223 (15.2) | |
bla CTX-M-10 | 76/204 (37.3) | 4/19 (21.1) | 80/223 (35.9) | |
bla CTX-M-25 | 2/204 (1.0) | 1/19 (5.3) | 3/223 (1.3) | |
bla CTX-M-55 | 3/204 (1.5) | 0 | 3/223 (1.3) | |
bla SHV-1 | 55/204 (27.0) | 0 | 55/223 (24.7) | |
bla SHV-2 | 2/204 (1.0) | 0 | 2/223 (0.9) | |
bla SHV-11 | 44/204 (21.6) | 3/19 (15.8) | 47/223 (21.1) | |
bla SHV-85 | 15/204 (7.4) | 0 | 15/223 (6.7) | |
bla TEM-1 | 19/204 (9.3) | 0 | 19/223 (8.5) | |
bla TEM-186 | 3/204 (1.5) | 0 | 3/223 (1.3) | |
bla CMY-2 | 7/204 (3.4) | 0 | 7/223 (3.1) | |
bla DHA-1 | 9/204 (4.4) | 0 | 9/223 (4.0) | |
bla FOX | 0 | 0 | 0 | |
Carbapenems (n = 16) | bla KPC-2 | 3/16 (18.8) | 0 | 3/223 (1.3) |
bla NDM-1 | 0 | 0 | 0 | |
bla IMP | 1/16 (6.3) | 0 | 1/223 (0.4) | |
bla VIM | 1/16 (6.3) | 0 | 1/223 (0.4) | |
bla OXA-48 | 5/16 (31.3) | 0 | 5/223 (2.2) |
n/N: No. of designated drug resistance-associated genes/No. of isolates resistant to the corresponding drugs.
n/N: No. of designated drug resistance-associated genes/No. of isolates susceptible to the corresponding drugs.
n/N: No. of designated drug resistance-associated genes/No. of all isolates.