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. 2012 Jul 31;7(7):e42280. doi: 10.1371/journal.pone.0042280

Table 4. Percentage of beta-lactamase antibiotics resistance-associated genes detected in K. pneumoniae isolates.

Target antimicrobial category Resistance-associated genes Resistance-associated genes detected in phenotypic resistant isolates, n/Na (%) Resistance-associated genes detected in phenotypic susceptible isolates, n/Nb (%) Resistance-associated genes detected in all isolates, n/Nc (%)
Antipseudomonal penicillins + beta-lactamase inhibitors, penicillins + beta-lactamase inhibitors, 1st and 2nd generation cephalosporins, 3rd and 4th generation cephalosporins, cephamycins (n = 204) bla CTX-M-1 35/204 (17.2) 2/19 (10.5) 37/223 (16.6)
bla CTX-M-2 1/204 (0.5) 1/19 (5.3) 2/223 (0.9)
bla CTX-M-3 31/204 (15.2) 1/19 (5.3) 32/223 (14.3)
bla CTX-M-8 20/204 (9.8) 2/19 (10.5) 22/223 (9.9)
bla CTX-M-9 18/204 (8.8) 2/19 (10.5) 20/223 (9.0)
bla CTX-M-14 37/204 (18.1) 0 37/223 (16.6)
bla CTX-M-15 34/204 (16.7) 0 34/223 (15.2)
bla CTX-M-10 76/204 (37.3) 4/19 (21.1) 80/223 (35.9)
bla CTX-M-25 2/204 (1.0) 1/19 (5.3) 3/223 (1.3)
bla CTX-M-55 3/204 (1.5) 0 3/223 (1.3)
bla SHV-1 55/204 (27.0) 0 55/223 (24.7)
bla SHV-2 2/204 (1.0) 0 2/223 (0.9)
bla SHV-11 44/204 (21.6) 3/19 (15.8) 47/223 (21.1)
bla SHV-85 15/204 (7.4) 0 15/223 (6.7)
bla TEM-1 19/204 (9.3) 0 19/223 (8.5)
bla TEM-186 3/204 (1.5) 0 3/223 (1.3)
bla CMY-2 7/204 (3.4) 0 7/223 (3.1)
bla DHA-1 9/204 (4.4) 0 9/223 (4.0)
bla FOX 0 0 0
Carbapenems (n = 16) bla KPC-2 3/16 (18.8) 0 3/223 (1.3)
bla NDM-1 0 0 0
bla IMP 1/16 (6.3) 0 1/223 (0.4)
bla VIM 1/16 (6.3) 0 1/223 (0.4)
bla OXA-48 5/16 (31.3) 0 5/223 (2.2)
a

n/N: No. of designated drug resistance-associated genes/No. of isolates resistant to the corresponding drugs.

b

n/N: No. of designated drug resistance-associated genes/No. of isolates susceptible to the corresponding drugs.

c

n/N: No. of designated drug resistance-associated genes/No. of all isolates.