Table 5. Percentage of non-beta-lactamase antibiotics resistance-associated genes detected in K. pneumoniae isolates.
| Target antimicrobial category | Resistance-associated genes | Resistance-associated genes detected in phenotypic resistant isolates, n/Na (%) | Resistance-associated genes detected in phenotypic susceptible isolates, n/Nb (%) | Resistance-associated genes detected in all isolates, n/Nc (%) |
| Folate pathway inhibitors (n = 118) | Dhfr | 52/118(44.1) | 10/105 (9.5) | 62/223 (27.8) |
| Fluoroquinolones (n = 90) | qnrA | 1/90 (1.1) | 1/133 (0.8) | 2/223 (0.9) |
| qnrB | 33/90 (36.7) | 6/133 (4.5) | 39/223 (17.5) | |
| qnrC | 1/90 (1.1) | 1/133 (0.8) | 2/223 (0.9) | |
| qnrD | 23/90 (25.6) | 12/133 (9.0) | 35/223 (15.7) | |
| qnrS | 22/90 (24.4) | 36/133 (27.1) | 58/223 (26.0) | |
| aac(6′)-Ib-cr | 45/90 (50.0) | 8/133 (6.0) | 53/223 (23.8) | |
| qepA | 1/90 (1.1) | 1/133 (0.8) | 2/223 (0.9) | |
| gyrA mutations | ||||
| T247A(Ser83Ile) | 18/90 (20.0) | 3/133 (2.3) | 21/223 (9.4) | |
| C248T (Ser83Phe) | 12/90 (13.3) | 3/133 (2.3) | 15/223 (6.7) | |
| A260C(Asp87Ala) | 13/90 (14.4) | 3/133 (2.3) | 16/223 (7.2) | |
| parC mutations | None | None | None | |
| Aminoglycosides (n = 110) | aacA4 | 50/110 (45.5) | 7/113 (6.2) | 57/223 (25.6) |
| aacC1 | 3/110 (2.7) | 0 | 3/223 (1.3) | |
| aacC2 | 66/110 (60.0) | 7/113 (6.2) | 73/223 (32.7) | |
| aadA1 | 49/110 (44.5) | 7/113 (6.2) | 56/223 (25.1) | |
| aadB | 4/110 (3.6) | 0 | 4/223 (1.8) | |
| aphA6 | 1/110 (0.9) | 0 | 1/223 (0.4) | |
| armA | 13/110 (11.8) | 0 | 13/223 (5.8) | |
| rmtB | 8/110 (7.3) | 0 | 8/223 (3.6) | |
a
n/N: No. of designated drug resistance-associated genes/No. of isolates resistant to the corresponding drugs.
b
n/N: No. of designated drug resistance-associated genes/No. of isolates susceptible to the corresponding drugs.
c
n/N: No. of designated drug resistance-associated genes/No. of all isolates.