Table 6. Transmissibility of drug resistance of ESBL positive MDR, XDR and PDR K. pneumoniae isolates by conjugation.
| K. pneumoniae isolates | Resistance profile of K. pneumoniae isolatesa,b | Resistance-associated genes detected in K. pneumoniae isolatesb |
| MDR isolates | ||
| TZSKP-9 | AMP,SAM,CFZ,CRO,CAZ,FEP,ATM,CIP,LVX,SXT,FD | bla CTX-M-14,dhfr |
| TZSKP-28 | AMP,SAM,CFZ,CRO,CAZ,FEP,ATM,GM,TOB,SXT,FD | bla SHV-11 |
| TZSKP-40 | AMP,SAM,CFZ,CRO,CAZ,FEP,ATM,GM,TOB,SXT,FD | bla CTX-M-14,bla CTX-M-10,bla SHV-11,bla TEM-1,qnrS,aacC2 |
| TZSKP-208 | AMP,SAM,CFZ,CRO,CAZ,FEP,ATM,SXT,FD | bla CTX-M-9,bla CTX-M-10,bla SHV-11,qnrS |
| XDR isolates | ||
| TZSKP-13 | AMP,SAM,CFZ,CRO,CAZ,FEP,ATM,CIP,LVX,TOB,AMK,SXT,FD | bla CTX-M-14,dhfr,qnrB,aacA4 |
| TZSKP-15 | AMP,SAM,CFZ,CRO,CAZ,FEP,CTT,ETP,IMP,ATM,CIP,LVX,GM,TOB,AMK,SXT,FD | bla CTX-M-1,bla CTX-M-14,bla CTX-M-10,bla SHV-11,bla TEM,dhfr,qnrA,qnrB,aac(6′)-Ib-cr,aacA4,aadA1 |
| TZSKP-146 | AMP,TZP,SAM,CFZ,CRO,CAZ,FEP,ATM,CIP,LVX,GM,TOB,AMK,SXT,FD | bla CTX-M-1,bla CTX-M-3,bla CTX-M-9,bla CTX-M-10,bla SHV-11,bla TEM,dhfr,qnrD,aac(6′)-Ib-cr,aacA4,aacC2,aadA1 |
| TZSKP-228 | AMP,TZP,SAM,CFZ,CRO,CAZ,FEP,CTT,ETP,IPM,ATM,TOB,AMK,SXT | bla CTX-M-3,bla CTX-M-10,bla SHV-11,bla TEM-1,bla KPC-2,bla IMP,bla VIM,bla OXA-48,dhfr,qnrD,qnrS,aac(6′)-Ib-cr,aacA4,aadB,aphA6 |
| PDR isolates | ||
| TZSKP-1 | AMP,TZP,SAM,CFZ,CRO,CAZ,FEP,CTT,ETP,IMP,ATM,CIP,LVX,GM,TOB,AMK,SXT,FD | blaCTX-M-3,blaCTX-M-10,blaSHV-11,dhfr,qnrB,aac(6′)-Ib-cr,aacA4,aacC2 |
| TZSKP-17 | AMP,TZP,SAM,CFZ,CRO,CAZ,FEP,CTT,ATM,CIP,LVX,GM,TOB,AMK,SXT,FD | bla CTX-M-2,bla CTX-M-14,bla CTX-M-10,bla SHV-11,bla TEM-1,bla CMY2,bla DHA1,dhfr,qnrS,aac(6′)-Ib-cr,aacA4,aacC2,aadA1 |
| TZSKP-82 | AMP,TZP,SAM,CFZ,CRO,CAZ,FEP,CTT,ETP,IPM,ATM,CIP,LVX,GM,TOB,AMK,SXT,FD | bla CTX-M-3,bla CTX-M-9,bla CTX-M-10,bla OXA-48,aac(6′)-Ib-cr,aacA4,aacC2,armA |
| TZSKP-245 | AMP,TZP,SAM,CFZ,CRO,CAZ,FEP,CTT,ETP,IPM,ATM,CIP,LVX,GM,TOB,AMK,SXT,FD | bla CTX-M-10,bla TEM-1,bla KPC-2,dhfr,aac(6′)-Ib-cr,aacA4,aacC2 |
a
Abbreviation of drugs: AMP, Ampicillin; TZP, Piperacillin/Tazobactam; SAM, Ampicillin/Sulbactam; CFZ, Cefazolin; CRO, Ceftriaxone; CAZ, Ceftazidime; FEP, Cefepime; CTT, efotetan; ETP, Ertapenem; IMP, Imipenem; ATM, Aztreonam; CIP, Ciprofloxacin; LVX, Levofloxacin; GM, Gentamycin; TOB, Tobramycin; AMK, Amikacin; SXT, Trimethoprim-Sulfamethoxazole; FD, Furadantin.
b
The ones found in both donor strains and transconjugants were underlined to demonstrate the difference.