Table 2. SIRT gene expression in human biopsies.
Human AK | SCC | |
Fold difference relative to normal adjacent tissue | ||
(Mean ± SEM) | ||
SIRT1 | 1.4±0.1 | 4.8±1.5* |
SIRT2 | 3.5±1.6* | 4.3±2.2* |
SIRT3 | 5.7±2.8* | 3.4±0.7* |
SIRT4 | 2.9±2.3 | 4.5±1.0* |
SIRT5 | 2.1±0.4* | 8.4±2.6* |
SIRT6 | 17.8±8.3* | 8.7±2.8* |
SIRT7 | 7.9±3.8* | 15.7±7.4* |
qPCR analyses of SIRT genes in skin biopsies.
Difference from normal adjacent tissue at *p<0.05 and a fold change of >1.5 or <0.67. n = 3 human biopsies each for AK and n = 5 for SCC, analyzed in triplicate.