Figure 5. The DKO mice are resistant to age-related obesity and glucose intolerance.

A. Northern blot analyses were performed to detect changes in p160 coactivator levels from 3 to 12 month old wild-type male mice. B. DKO mice remain lean at 12 months of age while the littermates become obese. C. Body weight gain is presented based on initial body weight of 3 month old male mice. D. GTT was performed with 12 month-old and sex-matched mice (5 for each genotype). * p<0.05, ** p<0.005, and *** p<0.0005.