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. 2012 Jul 31;7(7):e39026. doi: 10.1371/journal.pone.0039026

Figure 1. A Vista plot display of a multiple-species alignment of human ZIC2.

Figure 1

(A) ECRbase view of the vertebrate Zic2 regions (for these orthologs transcription from 5′ to 3′ is left to right) and where coding regions (blue), introns (orange), 3′ non-coding transcribed regions (yellow) and intergenic segments (red) are displayed. Vista plot peaks reflect the extent of homology (>50–100%) compared to the query sequence (human ZIC2 3′ UTR, 804 bp). (B) An enlargement of the two segments (pink: ECR#1_99 bp and ECR#2_367 bp) that retain conservation >50% between human and zebrafish in the 804 bp screened region (yellow). The positions of the polymorphic variations (green arrows) and unique variations (red arrows) are numbered from the last base of the stop codon (c.1599) of the human ZIC2 reference sequence (NM_007129.2).