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. 2012 Jul 31;7(7):e42005. doi: 10.1371/journal.pone.0042005

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© 2012 Winkeler et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Ctsk^Cre/+; Arf^fl/fl mice display both fibrosarcomas (top image) and lymphomas with splenomegaly (middle and bottom images). (B) Spontaneous tumor development occurred in all Ctsk^Cre/+; Arf^fl/fl mice.