. 2012 Jul 31;7(7):e42019. doi: 10.1371/journal.pone.0042019

Table 2. Efficacy of the Leuco-depletion and Leuco-depletion/Prion reduction filters on sheep Red Blood Cell concentrates.

	Whole blood	RBC – Leuco depletion filter		RBC leuco- depletion/prion reduction filter 1		RBC leuco- depletion/prion-reduction filter 2
		Pre-filtration	Post-filtration	Pre-filtration	Post-filtration	Pre-filtration	Post-filtration
Pool 1 Leucocytes (10⁶/mL)	6.3	1.06	<0.005	2.35	<0.005	1.39	<0.005
Pool 2 Leucocytes (10⁶/mL)	1.73	0.55	<0.005	0.47	<0.005	0.39	<0.005
Pool 3 Leucocytes (10⁶/mL))	3.75	2.97	0.005	0.49	<0.005	0.55	<0.005
Pool 4 Leucocytes (10⁶/mL)	1.82	0.52	<0.005	0.38	<0.005	0.33	<0.005
Pool 5 Leucocytes (10⁶/mL)	4.75	0.44	<0.005	0.17	<0.005	0.4	<0.005

Each whole blood pool was constituted by mixing 600–700 mL from 3 VRQ/VRQ sheep orally inoculated with PG127 classical scrapie isolate. Aliquots of 400 mL of whole blood were processed to prepare Red Blood Cell concentrate (RBC). RBCs were then filtered using either a leuco-depletion filter (Sepacell pure RC –Asahi) or two Leucodepletion depletion/Prion reduction filters (LD/PR). Filtered RBC volumes varied between 155 and 190 mL.