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. 2012 Aug;22(8):1477–1487. doi: 10.1101/gr.131912.111

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© 2012, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 3. — Illustration of the K-safety filter. (HP-read) Read with hairpin-forming potential. (NHP-read) Read without hairpin-making potential. (A) A read can simply be another known miRNA with an A:G mismatch to the source. (B) Read R₁ is an HP-read that has a C:T mismatch with read R₂. Read R₂ looks like the edited version of miR-421 with an A:G mismatch in position 4. (C) Shows a read, R, with a negative hairpin test (NHP-read), comprising only one mismatch with any known miRNA, M. The closest read with a positive hairpin to this read has more than K mismatches with it, thus the read R passes the K-safety filter.