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. 2012 Aug;22(8):1533–1540. doi: 10.1101/gr.131573.111

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© 2012, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 3. — Novel human miRNA editing sites detected in the pooled brain and frontal lobe samples and validated using in vitro overexpression experiments in U87 and U118 cell-lines. The editing levels in four miRNAs are shown: (A) miR-455 5p mature position 17, confirmed by ADARB1 overexpression in both U87 and U118 cell-lines; (B) miR-421 mature position 14, confirmed by ADARB1 overexpression in both U87 and U118 cell-lines; (C) miR-381 mature position 4, confirmed by ADAR overexpression in the U87 cell-line; and (D) miR-497 mature position 2, confirmed by ADARB1 overexpression in the U118 cell-line. If the editing site is detected in the mouse brain data of Chiang et al. (2010), the editing levels in this tissue are also presented. The number of sequencing reads supporting the editing site is indicated on the bar. (E,F) The predicted change in mRNA targets as a result of editing in the binding site of miR-381 and miR-497, respectively.