Table 4.

Relative hazard of hospitalized bacterial infection.

JIA medication exposure group	Referent Group	Unadjusted Relative Hazard (95% CI)	Adjusted* Relative Hazard (95% CI)
JIA: no current MTX, no current TNF inhibitor	ADHD	3.3 (2.6–4.1)	2.0 (1.5–2.5)
JIA: current MTX, no current TNF inhibitor	JIA: no current MTX, no current TNF inhibitor	1.3 (1.0–1.7)	1.2 (0.9–1.7)
JIA: current TNF inhibitor, irrespective of MTX	JIA: current MTX, no current TNF inhibitor	1.3 (0.9–1.9)	1.2 (0.8–1.8)

JIA = juvenile idiopathic arthritis; ADHD = attention-deficit hyperactivity disorder; MTX = methotrexate or leflunomide; TNF inhibitor = etanercept, infliximab, or adalimumab; GC = glucocorticoids

^*Adjusted for patient age, sex, race, hospitalized bacterial infection during baseline, outpatient bacterial infection during baseline, asthma, diabetes mellitus, GC dose on index date (none, low (< 10 mg prednisone equivalents per day), or high (≥ 10 mg prednisone equivalents per day)).