Table 2.
Characteristics of demented and non-demented autopsy participants in The 90+ Study 2003 cohort
| Characteristic | All Participants (N=104) | Not Demented (N=41) | Demented (N=63) | p-value1 |
|---|---|---|---|---|
|
| ||||
|
Median (Range)
| ||||
| Age at death (y) | 97.3 (92 – 106) | 97.9 (92 – 104) | 96.7 (92 – 106) | 0.19 |
|
| ||||
| Brain weight (g) | 1128 (871 – 1403) | 1157 (872 – 1390) | 1100 (871 – 1403) | 0.005 |
|
| ||||
| MMSE score at last visit | 18.0 (0 – 30) | 27 (16 – 30) | 11 (0 – 28) | <0.001 |
|
| ||||
| Last visit to death interval (months) | 3.8 (0.2 – 43.4) | 3.9 (0.3 – 25.9) | 3.8 (0.2 – 43.4) | 0.84 |
|
| ||||
| Postmortem - interval (hrs) | 4.9 (1.0 – 53.7) | 4.8 (2.2 – 20.8) | 5.0 (1.0 – 53.7) | 0.65 |
|
| ||||
|
Number (%)
| ||||
| Women | 82 (79) | 31 (75) | 51 (81) | 0.62 |
|
| ||||
| APOE e4 present | 24 (23) | 6 (15) | 18 (29) | 0.10 |
|
| ||||
| APOE e2 present | 17 (17) | 9 (22) | 8 (13) | 0.28 |
|
| ||||
| Braak tangle stage | ||||
| I – II | 23 (22) | 12 (29) | 11 (17) | 0.01 |
| III – IV | 40 (38) | 20 (49) | 20 (32) | |
| V – VI | 41 (39) | 9 (22) | 32 (51) | |
|
| ||||
| Neuritic plaques | ||||
| None | 18 (17) | 10 (24) | 8 (13) | 0.02 |
| Sparse | 24 (23) | 8 (20) | 16 (25) | |
| Moderate | 35 (34) | 18 (44) | 17 (27) | |
| Frequent | 27 (26) | 5 (12) | 22 (35) | |
|
| ||||
| Diffuse plaques | ||||
| None | 16 (15) | 8 (19) | 8 (13) | 0.15 |
| Sparse | 18 (17) | 7 (17) | 11 (17) | |
| Moderate | 24 (23) | 13 (32) | 11 (17) | |
| Frequent | 46 (44) | 13 (32) | 33 (52) | |
|
| ||||
| NIA-Reagan criteria | ||||
| None | 18 (17) | 10 (24) | 8 (13) | 0.03 |
| Low | 30 (29) | 11 (27) | 19 (30) | |
| Intermediate | 32 (31) | 16 (39) | 16 (25) | |
| High | 24 (23) | 4 (10) | 20 (32) | |
|
| ||||
| Hippocampal sclerosis | 11 (11) | 0 (0) | 11 (17) | 0.003 |
|
| ||||
| Diffuse Lewy body disease | 8 (8) | 0 (0) | 8 (13) | 0.02 |
|
| ||||
| Cerebral infarcts2 | 31 (30) | 10 (24) | 21 (33) | 0.38 |
1
p-values are for Wilcoxon rank sum test for continuous variables, Fisher’s exact test for binary variables, chi-square tests for categorical variables, and compare demented vs. not demented participants.
2
Includes large infarcts, lacunes, or micro-infarcts.
Abbreviations: MMSE=Mini-Mental State Exam; APOE=apolipoprotein; NIA=National Institute on Aging