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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Chromosome Res. 2012 Jul;20(5):635–656. doi: 10.1007/s10577-012-9290-3

Figure 3. Centromere proteins bind centromeric DNA with a non-uniform but stable pattern.

Figure 3

A. CenH3 localization at the centromere is stable through many rounds of mitotic and meiotic cell divisions. The entire LG II (top) or 0.5 Mb including Cen II (bottom) shows distribution of CenH3 in four different strains. Localization of CenH3 is similar in each strain and stable even following continued growth of NMF327 in race tubes. E, early time point, and L, late time point. B. The inner kinetochore proteins CEN-C and CEN-T colocalize with CenH3. LG IV and Cen IV coverage by CenH3, CEN-C and two replicates of CEN-T (CEN-T1 and CEN-T2) ChIP-seq. C. Binning CenH3 enrichment as reads per kb reveals periodicity in enrichment for three CenH3 replicates (CenH3 A–C), and to a lesser extent for CEN-C. CEN-T seems to be more evenly distributed.