Table 1. Centromere and kinetochore proteins in filamentous fungi.
Proteins were identified by Blast searches with the indicated human or S.pombe protein sequences as bait. Nomenclature for fungal homologs is currently uncertain; for N. crassa we propose “CEN-” and for Fusarium we propose “Cen”, in both cases followed by the letter code used for mammalian proteins. Here we provide current locus numbers based on annotations that can be found at the Fungal Genome Initiative website at the Broad Institute (http://www.broadinstitute.org/scientific-community/data). Many of these homologs had been previously identified (Meraldi et al., 2006) but annotations have been updated. “None”, no homolog was identified by sequence similarity.
| H. sapiens | S. pombe | N. crassa | F. graminearum | A. nidulans | M. oryzae |
|---|---|---|---|---|---|
| CENP-A | Cnp1 | NCU00145 | FGSG_02602.3 | ANID_06554.1 | MGG_06445.7 |
| HJURP | Scm3 | NCU03123 | FGSG_00678.3 | ANID_01514.1 | MGG_03695.7 |
| NPM1 | None | None | None | None | None |
|
| |||||
| CENP-B | None | None | None | None | None |
| None | None | NCU06592 | FGSG_05264.3 | None | MGG_01698.7 |
| None | None | NCU00392 | FGSG_07243.3 | ANID_04077.1 | MGG_13165.7 |
| Abp1 | ANID_09495.1 | ||||
| Cbh2 | ANID_08717.1 | ||||
| None | Cbh1 | None | None | ANID_06156.1 | None |
| INCENP | None | NCU05211 | FGSG_05106.3 | None | MGG_01835.7 |
| Aurora B | Ark1 | NCU00108 | FGSG_06959.3 | ANID_05815.1 | MGG_00479.7 |
|
| |||||
| CENP-C | Cnp3 | NCU09609 | FGSG_11834.3 | ANID_05115.1 | MGG_06960.7 |
| Mis18α/Mis18β | Mis18 | None | None | None | None |
| RbAp48/RbAp46 | Mis16 | NCU06679 | FGSG_06798.3: | ANID_08187.1 | MGG_07323.7 |
| M18BP1 | None | None | None | None | None |
| MgcRacGAP | None | None | None | None | None |
|
| |||||
| CENP-T | Cnp20 | NCU02161 | FGSG_08859.3 | ANID_04752.1 | MGG_02732.7 |
| CENP-X | Mhf2 | NCU09478 | FGSG_06022.3 | ANID_11893.1 | MGG_16148.7 |
| CENP-W | SPAC17G8.15 | NCU03400 | FGSG_10821.3 | ANID_10643.1 | MGG_11869.7 |
| CENP-S | SPBC2D10.16 | NCU03629 | FGSG_07161.3 | ANID_00598.1 | MGG_15064.7 |
|
| |||||
| CENP-H | Fta3 | NCU09996 | FGSG_00383.3 | ANID_02886.1 | MGG_04487.7 |
| CENP-I | Mis6 | NCU04131 | FGSG_07166.3 | ANID_06600.1 | MGG_09521.7 |
| CENP-K | Sim4 | NCU09238 | FGSG_01054.3 | ANID_02088.1 | MGG_17440.7 |
|
| |||||
| CENP-L | Fta1 | NCU07591 | FGSG_04225.3 | None | MGG_10701.7 |
| CENP-M | Mis17 | None | None | None | None |
| CENP-N | Mis15 | NCU03537 | FGSG_05172.3 | ANID_04360.1 | MGG_16236.7 |
|
| |||||
| CENP-O | Mal2 | NCU09100 | FGSG_08806.3 | ANID_04835.1 | MGG_12605.7 |
| CENP-P | Fta2 | NCU02135 | None | None | None |
| CENP-Q | Fta7 | NCU06791 | FGSG_10762.3 | None | MGG_06713.7 |
| CENP-R | None | None | None | None | None |
| CENP-U | Fta4 | NCU01005 | FGSG_02626.3 | ANID_01011.1 | MGG_15811.7 |
|
| |||||
| hMis12 | Mis12 | NCU06463 | FGSG_02525.3 | ANID_00960.1 | MGG_06304.7 |
| DSN1 | Mis13 | NCU01344 | FGSG_10141.3 | ANID_03187.1 | MGG_08211.7 |
| NNF1 | Nnf1 | NCU07571 | FGSG_05590.3 | ANID_08263.1 | MGG_04669.7 |
| NSL1 | Mis14 | NCU02262 | FGSG_10778.3 | ANID_04996.1 | MGG_00906.7 |
|
| |||||
| NDC80 | Ndc80 | NCU03899 | FGSG_09262.3 | ANID_04969.1 | MGG_01027.7 |
| NUF2 | Nuf2 | NCU06568 | FGSG_05288.3 | ANID_00166.1 | MGG_01848.7 |
| SPC24 | Spc24 | NCU05312 | FGSG_05313.1 | ANID_06224.1 | MGG_06076.7 |
| SPC25 | Spc25 | NCU11159 | FGSG_01538.3 | ANID_01392.1 | MGG_08566.7 |
|
| |||||
| KNL1 | Spc7 | NCU03103 | FGSG_00672.3 | ANID_05221.1 | MGG_03693.7 |
|
| |||||
| CENP-E | None | NCU02626 | FGSG_01004.3 | ANID_08286.1 | MGG_04366.7 |
| CENP-F | None | NCU03621 | FGSG_10111.3 | ANID_05829.1 | MGG_07274.7 |