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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Am J Transplant. 2012 May 8;12(8):1997–2007. doi: 10.1111/j.1600-6143.2012.04081.x

Figure 2. CsA increased Nox2 and TGF-β1-related proteins in NRK52E cells.

Figure 2

NRK52E cells were cultured in the presence of CsA (1μM and 10μM) or TGF-β1 (20 ng/ml) for 48 hours. Immunoblot analyses demonstrated a significant increase in phosphorylated (activated) p38MAPK, Smad3, and NFκB signaling molecules, as well as Nox2 and α-SMA protein levels in response to CsA and TGF-β1. The blot shown is a representative sample of three replicate studies, summarized in the bar graph.