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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Am J Transplant. 2012 May 8;12(8):1997–2007. doi: 10.1111/j.1600-6143.2012.04081.x

Figure 3. Calcineurin inhibitors dedifferentiated epithelial NRK52E cells.

Figure 3

We examined the effects of CsA and TAC treatment on tubular epithelial cell phenotype in vitro. CsA and TAC (10 μM for 48 hours) were associated with the loss of cobblestone morphology. Compared to controls and lower concentrations of CNIs, tubular cells treated with higher dose CsA and TAC displayed a spindle shape and loss of cell-cell contact suggestive of epithelial to mesenchymal transition (EMT).