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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Am J Transplant. 2012 May 8;12(8):1997–2007. doi: 10.1111/j.1600-6143.2012.04081.x

Figure 8. CsA Nephrotoxicity was reduced in Nox2−/− mice.

Figure 8

To specifically examine the role of Nox2 in the pathogenesis of CsA-induced nephropathy, we tested our hypothesis in wild type (C57Bl6/J) and Nox2 null (B6.129S-CybbTm1Din/J) mice (n=6 in each group). Trichrome staining demonstrated a significant reduction in collagen tubulointerstial staining in Nox2 null animals (a,b,c). Immunoblot analyses were consistent with this finding as the Nox2 knockout mice had significantly lower quantities of Nox2, α-SMA, and HNE following CsA treatment than the wild type mice (d,e).