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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Am J Transplant. 2012 May 8;12(8):1997–2007. doi: 10.1111/j.1600-6143.2012.04081.x

Figure 9. Nox2 was increased in human kidneys with CNI-induced fibrosis.

Figure 9

Immunohistochemical analyses of kidney biopsy samples from 15 liver transplant recipients with chronic CNI nephrotoxicity demonstrated a significant increase in both α-SMA and Nox2 compared to controls (a–d). Nox2 was upregulated in the tubules and interstitial cells of human kidneys undergoing CNI-induced fibrosis associated with either TAC or CsA (b–d). TAC was associated with less α-SMA staining than CsA by digital image analysis (d).