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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Am J Transplant. 2012 May 11;12(8):2017–2028. doi: 10.1111/j.1600-6143.2012.04073.x

Figure 3. Increased donor-reactive antibody production in B6.CCR5−/− recipients of B6.Kd cardiac allografts.

Figure 3

(A) Serum from wild-type C57BL/6 and B6.CCR5−/− allograft recipients was collected on day 10 post-transplant and tested for reactivity to B6.Kd thymocytes using flow cytometric based analyses to determine donor-reactive antibody titers. Data indicate mean titer ± SEM for n = 6/group and are representative of two independent experiments. **p<0.01. (B) On day 10 post-transplant, cardiac allografts were harvested from wild-type C57BL/6 recipients and from B6.CCR5−/− recipients. Methanol-fixed sections were stained with C4d specific antibody for immunohistochemical analysis. Sections shown are representative of 4 grafts analyzed in each group. Magnification, 200×.