Table 1.

Trials Comparing Natural and Protein-Free Synthetic Surfactants

Year	Authors	Surfactants Used	Participants	Endpoints of Trial	Results of Trial
1997	Hudak et al. [42]	Calfactant Colfosceril	871 Neonates <29 weeks GA	Incidence of RDS BPD Pneumothorax RDS-related mortality rate RDS-related mortality rate	Calfactant reduced the rate of RDS and RDS-related morality, but no difference in other endpoints
2001	Soll et al. [41] (Meta analysis)	Natural surfactant Synthetic protein-free surfactant	Premature neonates from 11 randomised control trials	Ventilator support Pneumothorax Mortality	Natural surfactants associated with lower rate of all endpoints