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When the bimodular PKS containing tcm minimal PKS and R1128 loading module are coexpressed with tailoring enzymes KR, act ARO/CYC, and act CYC, the desired compounds 8 and 9 were produced. The decarboxylated versions of 8 and 9 are 10 and 11, respectively. All three tailoring enzymes are able to process the unnatural alkyl-octaketide.
