Figure 1.

CF and non-CF pancreata at 83 to 90 days gestation and at birth. Eosinophilic zymogen material is abundant in all pancreatic acini in non-CF animals (eosinophilic staining). At 83 to 90 days gestation, CF pancreata exhibit reduced zymogen-filled mature acini (black arrows), which was associated with increased acini plugging and degeneration by luminal eosinophilic zymogen secretions (red arrow). This eventually results in further loss of normal zymogen-filled acini by birth (arrow). While less extensive in fetal versus neonatal CF pancreas, discrete patchy aggregates of lymphoid inflammation (arrowheads) expand the interstitium, with scattered neutrophils and macrophages occasionally seen in the lumen of adjacent ducts and acini, similar to the localization pattern of inflammation previously described in CF pig pancreas.^36,47 H&E. Scale bar = 100 μm.