FIG. 1.

Capillary glucose levels during the study. (A) An example of a patient managed with the Diabetes Insulin Guidance System (DIGS) software in Group II. This was a 58-year-old woman with a 13-year history of type 2 diabetes, complicated with neuropathy and nephropathy. (Upper panel) Insulin dosage. (Lower panel) Weekly mean glucose and events of hypoglycemia. During the first 4 weeks the subject continued to follow her current insulin dosage. During the active phase of the study (Weeks 4–16), the DIGS software adjusted each component of the basal-bolus regimen. Her total daily insulin dosage increased by 19% (from 123 to 151 units/day), but its distribution considerably changed, that is, different components in the regimen were diametrically redirected according to glucose patterns. (B) Weekly mean glucose (and regression lines) in Groups I and II. (C) Weekly mean glucose in Group III (because of fewer data points, a regression line was not plotted). (D) Weekly mean glucose (and regression line) of patients with and without frequent hypoglycemia. During the active 12 weeks weekly mean glucose improved when possible. A1C, glycosylated hemoglobin.