Table 6.

Adjusted Hazard Ratios for the Association of Lipoprotein Measure with Incident Type 2 Diabetes in Quintiles 1 through 5^a

	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	P for trend
Small LDL-P (nmol/L)	Ref.	1.54 (1.18–2.02)	2.09 (1.63–2.68)	2.62 (2.06–3.32)	4.04 (3.21–5.09)	<0.001
LDL-P size (nm)	4.16 (3.30–5.24)	3.04 (2.4–3.86)	2.21 (1.74–2.81)	1.63 (1.25–2.13)	Ref.	<0.001
Large VLDL-P (nmol/L)	Ref.	1.49 (1.09–2.05)	2.54 (1.91–3.39)	2.98 (2.24–3.96)	3.11 (2.35–4.11)	<0.001
VLDL-P size (nm)	Ref.	1.25 (0.97–1.62)	1.67 (1.32–2.10)	2.22 (1.78–2.76)	2.80 (2.27–3.46)	<0.001
Large HDL-P (μmol/L)	4.51 (3.68–5.52)	3.19 (2.58–3.94)	2.54 (2.04–3.15)	1.72 (1.36–2.17)	Ref.	<0.001
HDL-P (nm)	4.56 (3.50–5.93)	3.97 (3.03–5.21)	3.08 (2.35–4.03)	1.72 (1.29–2.29)	Ref.	<0.001

^aAdapted from Mora et al.¹³

Ranges (minimum–maximum) and hazard ratios with 95% confidence intervals are given for each quintile. P for trend obtained from using median quintile as a dependent variable in Cox regression models. Data represented are adjusted for age, race, randomized treatment assignment, smoking, exercise, education, menopausal status, hormone use, blood pressure, body mass index, family history of diabetes, HbA1c, and high-sensitivity C-reactive protein.

LDL-P, low-density lipoprotein particles; VLDL-P, very-low-density lipoprotein particles; HDL-P, high-density lipoprotein particles; HBA1c, glycosylated hemoglobin.