FIG. 3.

Results of an in silico study on 10 adult subjects who were given their basal rate and a bolus (8.0±3.8 units) for a 65-g carbohydrate meal at 150 min to simulate an over-bolus that may lead to hypoglycemia: (A) the control with no over-bolus, (B) the over-bolus protocol, (C–E) pump suspension protocol for 15-, 30-, and 60-min prediction horizon (PH) values, respectively, and (F–H) alert protocol for 15, 30 and 60 min PH values, respectively. False-positive alarms (open squares) and true-positive alarms (open circles) are shown for protocols without action (A and B). A value for successive alarms required of 2 was used throughout. CGM, continuous glucose monitor.