Table 1.
Mean pharmacokinetic parameters of peginesatide in the plasma of male Sprague–Dawley rats after IV administration.
| Dose (mg·kg−1) | Cmax (μg/mL) | t½ (h) | AUC0–t (μg·h/mL) | CL (mL/h/kg) | Vss (mL/kg) |
|---|---|---|---|---|---|
| 0.1 | 2.56 (0.162) | 17.5 (0.3) | 60.3 (4.71) | 1.65 (0.13) | 39.6 (3.03) |
| 0.5 | 13.5 (1.40) | 19.7 (2.6) | 388 (48.8) | 1.29 (0.18) | 39.5 (2.06) |
| 5 | 137 (6.19) | 31.6 (3.4) | 5405 (327) | 0.92 (0.06) | 39.6 (2.49) |
Each value represents the mean for three animals, values in parentheses represent SD.
The Cmax after intravenous administration represents the value at 0.25 h after administration.