Table 2.

Concentrations of the radioactivity in the tissues of albino rats after a single IV administration of 5 mg·kg⁻¹ [¹⁴C]-peginesatide.

	Concentration (μg equiv·g−1 or mL) at time after dose administration
Tissues/organs	0.25 h	6 h	24 h	7 Days	14 Days	30 Days	60 Days
Blood	80.9 ± 1.90	60.9 ± 4.36	39.7 ± 2.51	3.87 ± 0.291	1.03 ± 0.229	0.466 ± 0.054	0.170 ± 0.036
Plasma	131 ± 3.86	99.6 ± 2.94	64.1 ± 5.12	7.80 ± 0.541	2.00 ± 0.605	0.780 ± 0.099	0.232 ± 0.042
Brain	1.18 ± 0.030	0.939 ± 0.015	0.646 ± 0.050	0.200 ± 0.021	0.102 ± 0.014	0.080 ± 0.010	0.057 ± 0.006
Spinal cord	0.909 ± 0.289	0.662 ± 0.070	0.442 ± 0.090	0.129 ± 0.067	0.069 ± 0.030	0.033 ± 0.016	0.036 ± 0.018
Pituitary	13.2 ± 1.08	13.9 ± 2.71	13.7 ± 2.02	8.31 ± 0.594	6.25 ± 1.17	7.24 ± 0.292	4.32 ± 0.289
Eyes	0.346 ± 0.029	0.779 ± 0.168	0.806 ± 0.063	0.885 ± 0.111	0.765 ± 0.022	0.511 ± 0.147	0.299 ± 0.076
Harderian glands	1.15 ± 0.357	1.91 ± 0.183	2.55 ± 0.105	4.41 ± 0.100	5.21 ± 0.433	3.88 ± 0.907	2.75 ± 0.281
Submandibular lymph nodes	2.57 ± 0.038	4.25 ± 0.140	5.72 ± 0.303	10.6 ± 0.553	10.9 ± 1.32	7.86 ± 1.19	8.74 ± 1.22
Thyroid gland	8.25 ± 1.42	10.1 ± 1.79	10.2 ± 1.10	17.0 ± 5.26	13.2 ± 3.52	13.9 ± 3.33	8.03 ± 1.45
Thymus	0.669 ± 0.115	1.02 ± 0.040	1.90 ± 0.201	3.39 ± 0.560	1.81 ± 0.249	1.14 ± 0.138	1.15 ± 0.155
Heart	6.33 ± 0.512	7.71 ± 1.29	6.28 ± 0.256	4.01 ± 0.344	2.73 ± 0.254	1.57 ± 0.244	1.14 ± 0.205
Lungs	8.46 ± 0.824	8.37 ± 1.27	7.22 ± 0.464	4.26 ± 0.285	3.38 ± 0.703	1.78 ± 0.237	1.05 ± 0.238
Liver	7.03 ± 0.613	7.51 ± 0.438	9.26 ± 0.516	12.5 ± 0.727	8.53 ± 0.754	3.45 ± 0.808	1.17 ± 0.199
Spleen	4.62 ± 0.185	5.51 ± 0.776	10.2 ± 1.04	11.5 ± 0.204	23.6 ± 2.82	17.7 ± 4.96	3.40 ± 0.480
Pancreas	2.56 ± 0.036	3.83 ± 0.582	5.14 ± 0.582	9.74 ± 0.231	9.10 ± 0.629	6.67 ± 1.70	5.92 ± 0.436
Adrenals	8.45 ± 0.517	7.83 ± 1.38	10.0 ± 1.15	10.2 ± 1.31	9.15 ± 2.39	7.90 ± 1.57	5.32 ± 0.996
Kidneys	11.2 ± 1.48	10.6 ± 1.16	8.75 ± 1.47	5.68 ± 0.386	4.49 ± 1.02	3.03 ± 0.429	2.11 ± 0.574
Testes	1.14 ± 0.083	4.01 ± 0.254	4.15 ± 0.605	4.98 ± 0.222	5.19 ± 0.448	4.33 ± 1.00	5.10 ± 2.17
Skeletal muscle	0.569 ± 0.100	0.447 ± 0.037	0.584 ± 0.044	0.563 ± 0.119	0.379 ± 0.108	0.152 ± 0.012	0.085 ± 0.021
Skin	0.376 ± 0.103	1.41 ± 0.175	3.29 ± 0.308	3.06 ± 0.055	1.70 ± 0.109	0.889 ± 0.228	0.394 ± 0.080
Fat	0.861 ± 0.096	0.923 ± 0.308	1.65 ± 0.392	2.11 ± 0.693	1.14 ± 0.475	0.582 ± 0.070	0.456 ± 0.135
Bone (femur)	1.95 ± 0.128	1.53 ± 0.555	1.16 ± 0.177	0.788 ± 0.374	0.388 ± 0.054	0.278 ± 0.057	0.046 ± 0.001
Bone marrow	9.66 ± 0.367	8.66 ± 2.79	8.50 ± 1.23	8.87 ± 0.641	6.33 ± 0.683	4.12 ± 1.37	0.361 ± 0.142
Urinary bladder	2.40 ± 1.32	3.53 ± 0.234	6.18 ± 0.260	4.52 ± 1.01	2.30 ± 0.326	1.77 ± 0.889	0.967 ± 0.188
Stomach	1.32 ± 0.257	2.69 ± 0.013	3.01 ± 0.168	2.36 ± 0.262	2.00 ± 0.118	1.28 ± 0.106	0.590 ± 0.242
Intestine	1.47 ± 0.158	3.07 ± 0.233	3.10 ± 0.144	3.05 ± 0.259	1.78 ± 0.297	1.40 ± 0.183	0.624 ± 0.033

Each value is the mean ± SD for three animals.