Table 2.
Patient demographics.
| Overall | p16 negative | p16 positive | P value | |
|---|---|---|---|---|
| n | 106 | 36 | 70 | |
| Mean age (years) | 58.1 | 59.2 | 57.5 | 0.461∗ |
| Median followup (months) | 27.2 | 26.9 | 37.2 | |
| Gender | ||||
| Male | 83 (78.3%) | 25 (69.4%) | 58 (82.9%) | 0.113† |
| Female | 23 (21.7%) | 11 (30.6%) | 12 (17.1%) | |
| Received chemotherapy (%) | 65 (61.3%) | 18 (50.0%) | 47 (67.1%) | 0.086† |
| Habits (%) | ||||
| Tobacco use | 83 (78.3%) | 35 (97.2%) | 48 (68.6%) | 0.000†† |
| Alcohol use | 68 (64.2%) | 29 (80.6%) | 39 (55.7%) | 0.011† |
| Primary site (%) | 0.002†† | |||
| Tonsil | 58 (54.7%) | 20 (55.6%) | 38 (54.3%) | |
| Base of tongue | 41 (38.7%) | 10 (27.8%) | 31 (44.3%) | |
| Soft palate | 6 (5.7%) | 6 (16.7%) | 0 (0.0%) | |
| Pharyngeal wall | 1 (0.9%) | 0 (0.0%) | 1 (1.4%) | |
| Primary tumor classification | 0.467†† | |||
| T1 | 29 (27.4%) | 9 (25.0%) | 20 (28.6%) | |
| T2 | 52 (49.1%) | 16 (44.4%) | 36 (51.4%) | |
| T3 | 12 (11.3%) | 4 (11.1%) | 8 (11.4%) | |
| T4 | 13 (12.3%) | 7 (19.4%) | 6 (5.6%) | |
| Lymph node classification | 0.393†† | |||
| N0 | 14 (13.2%) | 7 (19.4%) | 7 (10.0%) | |
| N1 | 21 (19.8%) | 8 (22.2%) | 13 (18.6%) | |
| N2a | 9 (8.5%) | 1 (2.8%) | 8 (11.4%) | |
| N2b | 40 (37.7%) | 15 (41.7%) | 25 (35.7%) | |
| N2c | 18 (17.0%) | 4 (11.1%) | 14 (20.0%) | |
| N3 | 4 (3.8%) | 1 (2.8%) | 3 (4.3%) | |
| Stage group | 0.711†† | |||
| I | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |
| II | 10 (9.4%) | 5 (13.9%) | 5 (7.1%) | |
| III | 23 (21.7%) | 7 (19.4%) | 16 (22.9%) | |
| IVA | 69 (65.1%) | 23 (63.9%) | 46 (65.7%) | |
| IVB | 4 (3.8%) | 1 (2.8%) | 3 (4.3%) | |
| IVC | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |
| Histology | 0.007†† | |||
| Well differentiated | 5 (4.7%) | 2 (5.6%) | 3 (4.3%) | |
| Moderately differentiated | 33 (31.1%) | 15 (41.7%) | 18 (25.7%) | |
| Poorly differentiated | 29 (27.4%) | 12 (33.3%) | 17 (24.3%) | |
| Not otherwise specified | 9 (8.5%) | 5 (13.9%) | 4 (5.7%) | |
| Basaloid | 26 (24.5%) | 2 (5.6%) | 24 (34.3%) | |
| Lymphoepithelioma | 1 (0.9%) | 0 (0.0%) | 1 (1.4%) | |
| Papillary | 3 (2.8%) | 0 (0.0%) | 3 (4.3%) |
∗ t-test.
†Chi-square test.
††Fisher's exact test.