Table 3.
Univariate Cox regression analysis.
| Variable | Locoregional control | Disease-free survival | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI∗ | P value | Hazard ratio | 95% CI∗ | P value | |
| Age | 0.992 | 0.934–1.054 | 0.796 | 1.054 | 1.018–1.090 | 0.003 |
| Sex | 0.497 | 0.063–3.950 | 0.509 | 1.831 | 0.809–4.147 | 0.147 |
| Stage | 1.004 | 0.384–2.622 | 0.994 | 0.851 | 0.518–1.398 | 0.524 |
| Tobacco | 32.13 | 0.073–14061 | 0.263 | 1.807 | 0.690–4.733 | 0.229 |
| Alcohol | 6.764 | 0.850–53.83 | 0.071 | 1.713 | 0.793–3.702 | 0.171 |
| Chemotherapy | 0.266 | 0.069–1.031 | 0.055 | 0.307 | 0.144–0.657 | 0.002 |
| p16 | 0.105 | 0.022–0.497 | 0.005 | 0.155 | 0.070–0.341 | 0.000 |
| Cyclin D1 | 2.368 | 1.071–5.237 | 0.033 | 1.831 | 1.247–2.688 | 0.002 |
| HIF-1α (nuclear) | 1.339 | 0.986–1.818 | 0.061 | 1.233 | 1.011–1.503 | 0.039 |
| EGFR | 3.236 | 0.880–11.90 | 0.077 | 1.971 | 0.809–4.798 | 0.135 |
| Cyclophilin B | 1.787 | 0.501–6.382 | 0.371 | 1.447 | 0.742–2.821 | 0.278 |
| p21 | 1.679 | 0.751–3.754 | 0.206 | 1.235 | 0.802–1.901 | 0.338 |
| HIF-1α (cytoplasmic) | 0.910 | 0.601–1.377 | 0.655 | 0.941 | 0.743–1.192 | 0.615 |
| Carbonic anhydrase (membranous) | 1.075 | 0.888–1.303 | 0.458 | 0.991 | 0.869–1.130 | 0.890 |
| Carbonic anhydrase (cytoplasmic) | 0.659 | 0.307–1.413 | 0.284 | 0.969 | 0.763–1.231 | 0.797 |
| Major vault protein | 1.178 | 0.903–1.537 | 0.226 | 1.066 | 0.928–1.225 | 0.365 |
∗Confidence interval.