Table 4.

Dosing recommendations for patients on CRRT [25].

CRRT procedure	Estimated CrCL	Dose	Frequency	Infusion timea,b	Target attainment (MIC)
CVVH	≤30 mL/min	250 mg	q12h	4 hours	≤1 mg/L
CVVHDF	<5 mL/min	250 mg	q12h	4 hours	≤1 mg/L
CVVHDF	5–30 mL/min	500 mg	q12h	4 hours	≤1 mg/L

^aFor patients with acute kidney impairment on CRRT, an infusion time of 4 hours is required, taking into consideration the possible increases in nonrenal clearance of carbapenems in patients with acute renal insufficiency.

^bPatients with chronic kidney disease on CRRT can be treated with either a 1- or 4-hour infusion time. Based mainly on pharmacokinetic/pharmacodynamic considerations, a 4-hour infusion time may be more suitable to maximize the percentage time during the dosing interval that the free plasma concentration of doripenem exceeds the minimum inhibitory concentration (% fT > MIC).